Title:
MEDICINE COMPOSITION HAVING ANTICANCER ACTION, QUINAZORINE DERIVATIVE AND MAKING THEREOF
Document Type and Number:
Japanese Patent JPH05208911
Kind Code:
A
Abstract:
PURPOSE: To obtain an anticancer agent that contains quinazoline derivative as an active ingredient and shows the anticancer action caused by receptor tyrosine kinase inhibitory properties. CONSTITUTION: The compound represented by formula I [(i) R<1> is H, CF3 , NO2 ; n is 1; R<2> is a halogen, CF3 , NO2 , CN, an alkyl, an alkoxy, (di)alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl; (ii) R<1> is 5-, 6- or 8-chloro, 6-bromo; n is 1; R<2> is a halogen, an alkoxy] or its pharmaceutically acceptable salt, typically 4-(3'-methoxy-anilino)quinazoline or 7-chloro-4-(4'-chloro-2'-methylanilino)- quinazoline is used together with a pharmaceutically acceptable diluent or carrier. The compound of formula I is prepared by reaction of quinazoline of formula II with aniline.
Inventors:
ANDORIYUU JIYON BAAKAA
DEIBUIDO FUU DEIBUIIZU
DEIBUIDO FUU DEIBUIIZU
Application Number:
JP16741692A
Publication Date:
August 20, 1993
Filing Date:
June 25, 1992
Export Citation:
Assignee:
ICI PLC
International Classes:
A61K31/517; A61P35/00; A61K31/505; C07D239/94; (IPC1-7): A61K31/505; C07D239/94
Attorney, Agent or Firm:
Toshio Yano (1 outside)