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Patent Searching and Data


Title:
MEDICINE COMPOSITION FOR PROCEDURE OF SHOCK STATE BY IRRIGATION
Document Type and Number:
Japanese Patent JPH04364124
Kind Code:
A
Abstract:
PURPOSE: To prepare a pharmaceutical composition, capable of causing the sustained, deep and systemic vasodilation and useful for treating vascular hyporesponsiveness in a shock state such as sepsis or endotoxemia. CONSTITUTION: This pharmaceutical composition comprises an effective amount of (A) a compound represented by the formula (R1 and R4 are each H, CH3 or C2 H5 ; R2 is H or NO2 ; R3 is NHR4 , CH3 or C2 H5 ; R4 is each group in R1 ) alone or its mixture with (B) a cyclooxygenase blocker preferably selected from indomethacin and aspirin in an amount of preferably 10-500mg ingredient A alone and preferably 10-100mg ingredient A and 0.1-1mg ingredient B in the case of the indomethacin or 2-200mg ingredient B in the case of the aspirin when the mixture is used for the perfusion in a period of 1hr. The pharmaceutical composition is effective in treating a shock state by the perfusion. The ingredient A is a blocker for actions or production of endothelin-derived relaxing factor(EDRF) or a nitrogen oxidelike factor and is capable of recovering the response suppressed with catecholamine and effectively inhibiting the deterioration in vascular reactivity.

Inventors:
PIEERU BURAKU
PIEERUUECHIENNU SHIYABURIE DO
JIYANNMISHIERU GUIRON
MISHIERU OOGU
Application Number:
JP41911390A
Publication Date:
December 16, 1992
Filing Date:
December 25, 1990
Export Citation:
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Assignee:
SCRAS
International Classes:
A61K31/195; A61K31/198; A61K31/215; A61K31/405; A61K31/60; A61K45/06; A61K9/08; A61P9/00; A61P9/10; A61P39/00; A61P43/00; (IPC1-7): A61K9/08; A61K31/195; A61K31/215; A61K31/405; A61K31/615; A61K45/06
Attorney, Agent or Firm:
Shigeru Yagita (2 outside)