MEDICINE COMPOSITION FOR TREATING GRAFT-VERSUS-HOST DISEASE (GVHD) AND FOR SUPPRESSING GRAFT REJECTION IN ORGAN TRANSPLANTATION

Title:

MEDICINE COMPOSITION FOR TREATING GRAFT-VERSUS-HOST DISEASE (GVHD) AND FOR SUPPRESSING GRAFT REJECTION IN ORGAN TRANSPLANTATION

Document Type and Number:

Japanese Patent JPH10158192

Kind Code:

A

Abstract:

To obtain a preventive and a therapeutic agent having inhibitory actions on graft-versus-host disease and on graft rejection in organ transplantation, comprising a specific receptor agonist as an actives ingredient.

This composition comprises a retinoic acid receptor agonist, preferably a retinoic acid receptor subtype α agonist as an active ingredient. Preferably, the agonist is a condensed ring-containing carboxylic acid derivative of the formula [L ring and R ring are condensed to form a (substituted) hetero ring; ring A and ring B are each (substituted) aromatic hydrocarbon or a (substituted) hetero ring; D is a (protected) carboxyl], to be concrete, 4-{2-[5-(5,8- dimethylnaphthalene-2-y1)pyrrolyl]benzoic acid or 4-{2-[5-(4,7- dimethylbenzofuran-2-y1)pyrrolyl]}benzoic acid.

Inventors:

YAMAUCHI TOSHIHIKO
ISHIBASHI AKIRA
TOKUHARA NAOKI
NAGAI MITSUO

Application Number:

JP24642797A

Publication Date:

June 16, 1998

Filing Date:

September 11, 1997

Export Citation:

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Assignee:

EISAI CO LTD

International Classes:

C07D265/36; A61K31/19; A61K31/192; A61K31/203; A61K31/40; A61K31/4025; A61K31/415; A61K31/4427; A61K31/443; A61K31/4433; A61K31/455; A61K31/47; A61K31/495; A61K31/498; A61K31/535; A61K31/55; A61K31/695; A61K45/00; A61P37/06; A61P43/00; C07D207/337; C07D401/04; C07D403/04; C07D405/04; C07D405/06; C07D409/04; C07D413/04; (IPC1-7): A61K45/00; A61K31/19; A61K31/40; A61K31/415; A61K31/455; A61K31/47; A61K31/495; A61K31/535; A61K31/55; A61K31/695

Domestic Patent References:

JPH0971566A	1997-03-18
JPH11500448A	1999-01-12
JPH0276862A	1990-03-16
JPH02240058A	1990-09-25
JPS63255277A	1988-10-21
JPS49126637A	1974-12-04

Foreign References:

WO1996020913A1	1996-07-11
WO1996020914A1	1996-07-11
WO1997034869A1	1997-09-25

Other References:

PT MURPHY: "Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease", BONE MARROW TRANSPLANTATION, vol. 18, JPN4006010611, 1996, pages 641 - 642, XP000974473, ISSN: 0000746084
PT MURPHY: "Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease", BONE MARROW TRANSPLANTATION, vol. 18, JPNX006061755, 1996, pages 641 - 642, XP000974473, ISSN: 0000804298

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