PURPOSE: To obtain a medicine composition useful for treating osteoporosis, vitamin D dysbolism, chronic renal insufficiency, etc., comprising 1α,25- dihydroxycholecalciferol and a tocopherol.

CONSTITUTION: A medicine composition comprises 0.00001-0.001wt.% 1α,25- dihydroxycholecalciferol and 0.01-5wt.% tocopherol. The medicine composition is properly mixed with various additives useful for pharmaceutical preparation of common medicines such as crystalline cellulose, lactose, starch, mannitol, silicic anhydride, hydroxypropyl cellulose, magnesium stearate and anhydrous ethanol and pharmaceutically manufactured. The medicine composition can pharmaceutically be manufactured into a dosage form such as tablet, granule, fine granule or capsule. By addition of a tocopherol as a stabilizer, 1α,25- dihydroxycholecalciferol as an active ingredient can be prevented from decomposing and maintained stably.