Title:
MEDICINE FOR IMPROVING HEPATIC FUNCTION
Document Type and Number:
Japanese Patent JP3945846
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a medicine for preventing and treating diabetes, etc., or for improving hepatic functions by using a specific protein obtained in a large amount at a relatively low cost.
SOLUTION: This medicine for improving the hepatic functions contains betacellulin protein (hereinafter referred to as BTC protein) or its mutein as an active ingredient. The BTC protein is a protein factor produced by a pancreatic beta tumor cell originated from a transgenic mouse. The BTC protein is preferably a protein having e.g. a sequence of the formula. Especially, a protein having an amino acid sequence expressed by at least a sequence number selected from the sequence number group of 3, 4, 5 and 6 is preferable. A protein having an amino acid sequence of the sequence number 1 or 2 is further preferable. The mutein of the BTC protein is suitably a protein having an amino acid sequence obtained by deleting twelve or thirty amino acids from the N- terminal of the amino acid sequence expressed by the sequence number 1. Further, the simultaneous employment of activin is further preferable.
Inventors:
Itaru Kojima
Application Number:
JP29620196A
Publication Date:
July 18, 2007
Filing Date:
November 08, 1996
Export Citation:
Assignee:
Takeda GmbH
International Classes:
A61K38/00; A61K38/04; A61K38/27; A61P1/00; A61P3/08; A61P3/10; A61P43/00; C07K7/06; C07K7/08; C07K14/47; (IPC1-7): A61K38/00; A61K38/00; A61K38/27; A61K38/04; //C07K7/06; C07K7/08; C07K14/47
Domestic Patent References:
| JP6087894A |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Eiji Katayama
Kaoru Kuroda
Takayuki Hirose
Shuichi Takahashi
Tsutomu Uchiyama
Tadao Asahina
Junko Kobayashi
Eiji Katayama
Kaoru Kuroda
Takayuki Hirose
Shuichi Takahashi
Tsutomu Uchiyama
Tadao Asahina