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Title:
MEDICINE-RELEASING TIME-CONTROLLING TYPE SOLID PREPARATION
Document Type and Number:
Japanese Patent JP2003171277
Kind Code:
A
Abstract:

To provide a medicine-releasing time-controlling type solid preparation having a so-called pulse type releasing characteristic, i.e., exhibiting a prescribed lag time until the initiation of release of the medicine after administering an oral carbapenem-based antibiotic agent as the medicine and releasing the medicine quickly, which is constant and does not depend on a pH of body liquid.

This medicine-releasing time-controlling type solid preparation consisting of an at least 2-layered structure in which a core layer containing the oral carbapenem-based antibiotic agent as the medicine is covered by an outer layer not containing the medicine is characterized by containing a hydrophobic material, (A) a low viscosity hydroxypropylcellulose and/or (B) a high viscosity hydroxypropylcellulose as outer layer components and controlling the releasing time of the medicine by making the blending ratio of the (A)/(B) as (10/0)-(0/10). As the hydrophobic material in the outer layer components, a microcrystalline cellulose is used.


Inventors:
NEGISHI HIROSHI
MIYAJI TATEAKI
Application Number:
JP2001375036A
Publication Date:
June 17, 2003
Filing Date:
December 07, 2001
Export Citation:
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Assignee:
WYETH LEDERLE JAPAN LTD
International Classes:
C07D477/00; A61K9/36; A61K9/50; A61K9/62; A61K31/427; A61K47/38; A61P31/04; (IPC1-7): A61K31/427; A61K9/36; A61K9/50; A61K9/62; A61K47/38; A61P31/04; C07D477/00
Attorney, Agent or Firm:
Kusama Attack