Title:
Ｎ－アシル－Ｘ－グルタミンジペプチドを含む培地
Document Type and Number:
Japanese Patent JP7175908
Kind Code:
B2
Abstract:
The present invention relates to improved culture media for use in biotechnological production processes, processes employing such improved media, and to products obtained from such processes. The cell culture media of the present invention comprise L-glutamine from a set of N-acylated dipeptides Acyl-X-Q and L-glutamine from a set of other glutamine-sources Qsource in a defined molar ratio R = n(Acyl-X-Q) / n(Qsource); wherein X is defined as an L-amino acid;
wherein Q is defined as L-glutamine attached via an amide bond to L-amino acid X;
wherein Acyl is defined as a C 1 -C 7 -acyl moiety attached via an amide bond to the amino-terminus of L-amino acid X;
wherein R is defined to be in the range of 0,03 to 20;
wherein n(Acyl-X-Q) is the total amount of substance of L-glutamine contained in the set of N-acylated dipeptides Acyl-X-Q in the culture media; and
wherein n(Qsource) is the total amount of substance of L-glutamine contained in the set of other glutamine sources Qsource in the culture media.
Inventors:
Gunter Knaup
Friedhelm Merz
Friedhelm Merz
Application Number:
JP2019548006A
Publication Date:
November 21, 2022
Filing Date:
March 02, 2018
Export Citation:
Assignee:
Evonik Operations Gem Beher
International Classes:
C12N5/071; C12N5/09
Domestic Patent References:
| JP4187697A | ||||
| JP4305596A |
Other References:
AMB Express.,2016年,Vol.6, No.48,pp.1-12
Biotechnol Prog.,2013年,Vol.29, No.1,pp.165-175
Cytotechnology,2013年01月,Vol.65, No.1,pp.135-143
Biotechnol Prog.,2013年,Vol.29, No.1,pp.165-175
Cytotechnology,2013年01月,Vol.65, No.1,pp.135-143
Attorney, Agent or Firm:
Patent Attorney Corporation Ashitaba International Patent Office