To provide four kinds of splice mutants of a membrane receptor to a steroid or a sterol, and to provide a usage of the same.
A receptor polypeptide to a steroid or a sterol contains various domains, that is leucine rich repetition domains, ankyrin domains and a kinase domain. The polypeptide has a membrane binding property. After the polypeptide is bound to a steroid or a sterol, the kinase domain phosphorylates serine and threonine radicals of a protein to elicit an intracellular signal cascade. The polypeptide contains 600 amino acids, and it contains island domains found between leucine rich repeat domains of the polypeptide. An island domain relates to steroid bonding or sterol bonding. The polypeptide is useful for screening and manufacturing a medicine for a steroid hormone depending disease, and it can be used for such purposes.
LESSL MONIKA
FRITZEMEIER KARL-HEINRICH
TOSCHI LUISELLA
