抗癌剤としてのメルカプトプリン誘導体

Title:

抗癌剤としてのメルカプトプリン誘導体

Document Type and Number:

Japanese Patent JP2010520194

Kind Code:

A

Abstract:

The invention provides novel mercaptopurine derivatives, e.g., S-allylthio-6-mercaptopurine and S-allylthio-6-mercaptopurine 9-riboside, as well as pharmaceutical compositions thereof. These compounds are highly efficient anti-proliferative agents, thus can be useful for treatment of various diseases or disorders, in particular, proliferative, inflammatory, skin and immune diseases or disorders.

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Inventors:

Milon, thalia
Rabinkov, Aharon
Millerman, David
Wilchek, Meir

Application Number:

JP2009551311A

Publication Date:

June 10, 2010

Filing Date:

March 02, 2008

Export Citation:

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Assignee:

Milon, thalia

International Classes:

C07D487/04; A61K31/52; A61K31/7076; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/08; A61P17/10; A61P19/02; A61P19/08; A61P21/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; C07H19/167

Domestic Patent References:

JPS4539709B1

Foreign References:

US6552060B1	2003-04-22
GB993302A	1965-05-26

Other References:

JPN5010005411; ＭＵＬＬＥＲ　Ｃ　Ｅ: ＩＮＴＥＲＮＡＴＩＯＮＡＬ　ＪＯＵＲＮＡＬ　ＯＦ　ＰＨＡＲＭＡＣＥＵＴＩＣＳＶ５７　Ｎ１, 1989, Ｐ４１-４７
JPN5010005413; ＩＮＯＭＡＴＡ　ＭＯＴＯＫＯ: ＪＯＵＲＮＡＬ　ＯＦ　ＰＨＡＲＭＡＣＯＢＩＯ-ＤＹＮＡＭＩＣＳＶ４　Ｎ１２, 1981, Ｐ９２８-９３２
JPN5010005429; ＳＡＮＥＹＯＳＨＩ　ＭＩＮＥＯ: ＪＯＵＲＮＡＬ　ＯＦ　ＰＨＡＲＭＡＣＯＢＩＯ-ＤＹＮＡＭＩＣＳＶ１　Ｎ３, 1978, Ｐ１６８-１７４

Attorney, Agent or Firm:

Asamura patent office
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe

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