Title:
水疱性表皮剥離症緩和または改善用間葉系幹細胞−ハイドロゲル−生分解性または間葉系幹細胞−ハイドロゲル−非分解性支持体組成物
Document Type and Number:
Japanese Patent JP6810706
Kind Code:
B2
Abstract:
The present invention relates to a composition and a sheet, including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support and a preparing method thereof. More specifically, in the sheet including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support according to the present invention, the high-active mesenchymal stem cells may be applied to a wounded part of a patient with epidermolysis bullosa as it is without isolation using proteases, and in the culturing, an extracellular matrix such as collagen, laminin, fibronectin, and elastin secreted from the mesenchymal stem cells is wholly present on the hydrogel to have an advantageous effect that skin reproduction and re-epithelization abilities are significantly excellent as compared with conventional dressing agents used for epidermolysis bullosa.
Inventors:
Lee, Song
Kim, Mihyun
Kim, Mihyun
Application Number:
JP2017553411A
Publication Date:
January 06, 2021
Filing Date:
April 12, 2017
Export Citation:
Assignee:
ANTEROGEN CO.,LTD.
International Classes:
A61K35/28; A61K9/70; A61K38/39; A61K47/50; A61K47/58; A61K47/59; A61K47/61; A61K47/65; A61P17/00; A61P43/00
Domestic Patent References:
| JP2001517688A |
Foreign References:
| WO2015105249A1 | ||||
| WO2015138502A1 |
Other References:
Molecular Therapy,2013年,Vol.21,No.7,p.1335-1344
Matrix Biol,2007年,Vol.26,No.2,p.106-114
J Extracellular Vesicles,2015年,Vol.4,Suppl.1,p.55,演題番号P-V-12
Matrix Biol,2007年,Vol.26,No.2,p.106-114
J Extracellular Vesicles,2015年,Vol.4,Suppl.1,p.55,演題番号P-V-12
Attorney, Agent or Firm:
sk patent corporation
Akihiko Okuno
Hiroyuki Ito
Akihiko Okuno
Hiroyuki Ito