Title:
エクテイナシジン743の代謝産物
Document Type and Number:
Japanese Patent JP4583598
Kind Code:
B2
Abstract:
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM" followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
Inventors:
Kennis El Reinhardt
Jose Jay Morales
Joel Reed
Isabelle Raymundo
Pablo Floriano
Laura Garcia Gravaros
Jose Jay Morales
Joel Reed
Isabelle Raymundo
Pablo Floriano
Laura Garcia Gravaros
Application Number:
JP2000547976A
Publication Date:
November 17, 2010
Filing Date:
May 11, 1999
Export Citation:
Assignee:
Pharma Mar Sociedad Anonima
International Classes:
C07D515/22; A61K31/357; A61K31/36; A61K31/39; A61K31/47; A61K31/472; A61K31/4747; A61K31/4995; A61K35/02; A61P35/00; C07D217/10; C07D217/24; C07D317/44; C07D317/64; C07D317/66; C07D327/02; C07D411/14; C07D491/14; C07D497/22
Domestic Patent References:
| JP1502749A |
Foreign References:
| WO1998046080A1 | ||||
| US5478932 |
Other References:
J. Am. Chem. Soc.,1996年,118,9017-9023
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro