Title:
テトラアザ大員環誘導体の金属錯体
Document Type and Number:
Japanese Patent JP5518465
Kind Code:
B2
Abstract:
Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof.
Inventors:
Moore, Denise A.
Application Number:
JP2009500476A
Publication Date:
June 11, 2014
Filing Date:
March 14, 2007
Export Citation:
Assignee:
Mallinck Rod LRC
International Classes:
C07D257/02; A61K49/00; A61K49/04; A61K51/00; C07F1/04
Domestic Patent References:
| JP2000510880A | ||||
| JP4504247A | ||||
| JP2004515545A | ||||
| JP2004509152A | ||||
| JP7506365A | ||||
| JP5099919B2 |
Other References:
BRUNNER,U. et al.,Cu2+ COMPLEXES OF TETRAAZACYCLODODECANES FUNCTIONALIZED WITH BENZYL SIDE CHAINS CARRYING CARBOXYLIC OR PHENOLIC GROUPS,Supramolecular Chem.,1993年,Vol.2, No.2-3,p.103-10
WOODS,M. et al,Synthesis, Relaxometric and Photophysical Properties of a New pH-Responsive MRI Contrast Agent: The Effect of Other Ligating Groups on Dissociation of a p-Nitrophenolic Pendant Arm,J. Am. Chem. Soc.,2004年 7月10日,Vol.126, No.30,p.9248-56
TERRENO,E. et al,A multinuclear NMR relaxometry study of ternary adducts formed between heptadentate GdIII chelates and L-lactate,Chemistry--A European Journal,2005年 7月12日,Vol.11, No.19,p.5531-5537
NICOLLE,G.M. et al,From monomers to micelles: investigation of the parameters influencing proton relaxivity,JBIC, Journal of Biological Inorganic Chemistry,2002年 3月23日,Vol.7, No.7-8,p.757-769
EISENWIENER,K. et al,A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling,Bioorganic & Medicinal Chemistry Letters,2000年,Vol.10, No.18,p.2133-2135
ANSARI,M.H. et al,Synthesis of N-[3-(p-aminophenyl)-1-carboxypropyl] derivatives of 1,4,7-triazacyclononane-N,N'-diacetic acid and 1,4,7,10-tetraazacyclododecane-N,N',N''-triacetic acid: macrocyclic bifunctional chelating agents useful for antibodies labelling,Bioorganic & Medicinal Chemistry Letters,1993年,Vol.3, No.6,p.1071-2
WOODS,M. et al,Synthesis, Relaxometric and Photophysical Properties of a New pH-Responsive MRI Contrast Agent: The Effect of Other Ligating Groups on Dissociation of a p-Nitrophenolic Pendant Arm,J. Am. Chem. Soc.,2004年 7月10日,Vol.126, No.30,p.9248-56
TERRENO,E. et al,A multinuclear NMR relaxometry study of ternary adducts formed between heptadentate GdIII chelates and L-lactate,Chemistry--A European Journal,2005年 7月12日,Vol.11, No.19,p.5531-5537
NICOLLE,G.M. et al,From monomers to micelles: investigation of the parameters influencing proton relaxivity,JBIC, Journal of Biological Inorganic Chemistry,2002年 3月23日,Vol.7, No.7-8,p.757-769
EISENWIENER,K. et al,A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling,Bioorganic & Medicinal Chemistry Letters,2000年,Vol.10, No.18,p.2133-2135
ANSARI,M.H. et al,Synthesis of N-[3-(p-aminophenyl)-1-carboxypropyl] derivatives of 1,4,7-triazacyclononane-N,N'-diacetic acid and 1,4,7,10-tetraazacyclododecane-N,N',N''-triacetic acid: macrocyclic bifunctional chelating agents useful for antibodies labelling,Bioorganic & Medicinal Chemistry Letters,1993年,Vol.3, No.6,p.1071-2
Attorney, Agent or Firm:
Takeshi Oshio