Title:
メタニューモウイルス株、そのワクチン製剤における用途、抗原性配列の発現のためのベクターとしての用途、並びにウイルス増殖方法
Document Type and Number:
Japanese Patent JP2007525178
Kind Code:
A
Abstract:
The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.
Inventors:
Haller, Aurelia
Tan, Roderick
Fuché, Lonardus, Adrián, Maria
Van den Hogen, Bernadetta, Geralda
Hostel House, Albertos, Dominux, Marcelinus, Erasmus
Tan, Roderick
Fuché, Lonardus, Adrián, Maria
Van den Hogen, Bernadetta, Geralda
Hostel House, Albertos, Dominux, Marcelinus, Erasmus
Application Number:
JP2006513301A
Publication Date:
September 06, 2007
Filing Date:
April 23, 2004
Export Citation:
Assignee:
Med Immune Baxines, Incorporated
Vironovative Beevy
Vironovative Beevy
International Classes:
C12N7/00; A61K39/00; A61K39/12; A61K39/155; A61K39/205; A61K39/295; A61P11/00; A61P31/12; A61P31/16; A61P31/18; C07K14/115; C12N7/02; C12N7/04; C12N15/09; C12N15/86; C12Q1/68; G01N33/53; G01N33/566; G01N33/569; C12N
Foreign References:
| WO2002057302A2 | 2002-07-25 | |||
| WO2002044334A2 | 2002-06-06 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita