Title:
クレアチン、クレアチン一水和物、またはグアニジノ酢酸の製造方法
Document Type and Number:
Japanese Patent JP5345518
Kind Code:
B2
Abstract:
A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or glycinate solutions that are obtained in this manner are finally reacted under acidic conditions with a guanylating agent such as for example O-alkylisourea or cyanamide. In this manner products are obtained in high yields and very good purity where in contrast to the prior art no traces whatsoever of hydrocyanic acid, formaldehyde, chloroacetic acid or ammonia are present. The formation of the toxicologically critical dihydrotriazine is also avoided.
Inventors:
Franz Tarhammer
Thomas Gastner
Thomas Gastner
Application Number:
JP2009503495A
Publication Date:
November 20, 2013
Filing Date:
April 05, 2007
Export Citation:
Assignee:
AlzChem AG
International Classes:
C07C277/08; C07C227/02; C07C229/08; C07C229/10; C07C279/14; C07B61/00
Domestic Patent References:
| JP9031043A | ||||
| JP2000229936A | ||||
| JP2000191625A | ||||
| JP11209335A | ||||
| JP2002524548A |
Foreign References:
| US6326513 | ||||
| WO1992009559A1 | ||||
| DE19920962A1 |
Attorney, Agent or Firm:
Toshio Yano
Takuya Kuno
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Takuya Kuno
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard