Title:
ジペプチジルペプチダーゼIV阻害剤およびその中間体の製造方法
Document Type and Number:
Japanese Patent JP5210406
Kind Code:
B2
Abstract:
A process for preparing an amine of the structure
which comprises
a. treating an aqueous solution of a keto acid of the structure
with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and
b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions.
Inventors:
Michael politino
Matthew M. Cadin
Paul M. Sconezny
Chen Jason Gee
Matthew M. Cadin
Paul M. Sconezny
Chen Jason Gee
Application Number:
JP2011057781A
Publication Date:
June 12, 2013
Filing Date:
March 16, 2011
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C12P13/02; C07D209/52; C07H21/04; C12N1/06; C12N1/21; C12N9/02; C12N9/06; C12N15/74; C12P13/04; C12P13/22; C12P15/00; C12P17/10; C12P21/06; C12N9/04; C12N15/09
Foreign References:
| WO2004052850A1 |
Other References:
Bioorg. Chem.,1990年,Vol.18,p.116-130
Bioorg. Med. Chem.,1999年,Vol.7,p.2247-2252
Enzy. Microb. Technol.,2000年,Vol.26,p.348-358
Bioorg. Med. Chem.,1999年,Vol.7,p.2247-2252
Enzy. Microb. Technol.,2000年,Vol.26,p.348-358
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto