Title:
プロブコールおよびその誘導体のエステルおよびエーテルの製造方法
Document Type and Number:
Japanese Patent JP4550800
Kind Code:
B2
Abstract:
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion is then reacted with an ester or ether forming compound.
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Inventors:
Weingarten, M. David
Sikorski, The Aims A
Sikorski, The Aims A
Application Number:
JP2006500935A
Publication Date:
September 22, 2010
Filing Date:
January 13, 2004
Export Citation:
Assignee:
Aserodynics Incorporated
International Classes:
C07C323/20; C07C319/20
Domestic Patent References:
| JP2005508850A | ||||
| JP2002503227A | ||||
| JP7506373A |
Foreign References:
| US6323359 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura