Title:
ピリド[2,3-d]ピリミジン-7-オンおよび3,4-ジヒドロピリミド[4,5-d]ピリミジン-2(1H)-オン誘導体の製造方法
Document Type and Number:
Japanese Patent JP2008537937
Kind Code:
A
Abstract:
The present invention is directed to a novel method of preparing of 2,4,8-trisubstituted pyrido[2,3-d]pyrimidin-7-one pharmacophores of Formula (II) or (IIa) wherein G1 is CH2; G2 is CH; Rx is chloro, bromo, iodo, or O-S(O)2CF3; Rg is a C1-10 alkyl; m is 0, or an integer having a value of 1, or 2; R3 is a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-10 alkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic or a heterocyclylC1-10 alkyl moiety, and wherein each of these moieties may be optionally substituted. which comprises reacting a compound of the formula: wherein Ry is chloro, bromo, iodo, O-S(O)2CF3; and Rg is a C1-10 alkyl; with a olefin forming reagent in a suitable base to yield a compound of Formula (II), or (IIa) wherein m=0 and oxidizing the sulphur as necessary or desired.
Inventors:
James Francis Callahan
Jeffrey Baume
One Zehon
Yang Hong Shin
Jeffrey Baume
One Zehon
Yang Hong Shin
Application Number:
JP2008503241A
Publication Date:
October 02, 2008
Filing Date:
March 24, 2006
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
C07D471/04; B01J31/24; C07D487/04; A61K31/519; A61P43/00; C07B61/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita