Title:
酵素的還元による(R)-および(S)-8-クロロ-6-ヒドロキシ-オクタン酸アルキルエステルの製造方法
Document Type and Number:
Japanese Patent JP2005506091
Kind Code:
A
Abstract:
The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II in which R has the meaning C1-4-alkyl, from 8-chloro-6-oxooctanoic acid alkyl esters of the general formula I in which R has the above meaning, by enzymatic reduction using alcohol dehydrogenases, such as Lactobacillus brevis or Thermoanaerobium brokii, in the presence of cofactor regeneration systems. The resulting (R)- and (S)-8-chloro-6-hydroxyoctanoic acid esters can be converted in a known manner into (R)-alpha-lipoic acid and (S)-alpha-lipoic acid, respectively.
Inventors:
Michael Muller
Wolfgang Sauer
Gunter Ravant
Wolfgang Sauer
Gunter Ravant
Application Number:
JP2003538385A
Publication Date:
March 03, 2005
Filing Date:
October 14, 2002
Export Citation:
Assignee:
VIATRIS GmbH & Co.KG
International Classes:
C07D339/04; C12P1/00; C12P7/42; C12P7/62; C12P17/00; C12R1/01; (IPC1-7): C12P7/62; C12P17/00
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel