Title:
(S)-3-(アミノメチル)-5-メチルヘキサン酸を製造する方法
Document Type and Number:
Japanese Patent JP3874306
Kind Code:
B2
Abstract:
A method of making (+/-)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with to form primarily reacting the with a cyanide source to form decarboxylating the to form hydrolyzing the with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (+/-)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (+/-)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with to form primarily reacting the with a cyanide source to form decarboxylating the to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (+/-)-3-(aminomethyl)-5-methylhexanoic acid.
Inventors:
Grote, Todd Michael
Hatsukaby, Brian Keith
Mulhan, thomas
Sobe Rye, Dennis Martin
Titus, Robert Daniel
Hatsukaby, Brian Keith
Mulhan, thomas
Sobe Rye, Dennis Martin
Titus, Robert Daniel
Application Number:
JP50055997A
Publication Date:
January 31, 2007
Filing Date:
May 13, 1996
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
C07B57/00; C07C59/50; C07C229/08; C07C227/04; C07C227/10; C07C227/26; C07C227/34; C07C227/42; C07C253/10; C07C255/19; C07C255/22
Foreign References:
| WO1993023383A1 |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura