Title:
擬似移動床クロマトグラフィーを用いる中性ヒトミルクオリゴ糖の精製方法
Document Type and Number:
Japanese Patent JP6666243
Kind Code:
B2
Abstract:
The present application discloses a process for the purification of 2'-fucosyllactose produced by fermentation, enzymatic synthesis or chemical synthesis or combinations thereof. The process uses simulated moving bed (SMB) chromatography which allows the continuous purification of large quantities of 2'-fucosyllactose at high purity. Contrary to the purification currently used in chemical synthesis route of 2'-fucosyllactose, the presented process allows the provision of 2'-fucosyllactose free of noxious chemicals like e.g. trace amounts of heavy metals or organic solvents. 2'-fucosyllactose may be obtained in solid form by spray drying. The provided 2'-fucosyllactose is very well-suited for use in food applications.
Inventors:
Jennevine, Stephan
Helflich, Marx
Helflich, Marx
Application Number:
JP2016520025A
Publication Date:
March 13, 2020
Filing Date:
October 02, 2014
Export Citation:
Assignee:
Jennewein Biotechnologie GmbH
International Classes:
C07H5/04; B01D15/00; B01D15/12; B01D15/36; C07H7/02
Domestic Patent References:
| JP2012529274A | ||||
| JP6039206A | ||||
| JP2008061531A | ||||
| JP2286695A | ||||
| JP6253879A |
Foreign References:
| WO2012112777A1 | ||||
| CN102676604A | ||||
| WO2012156898A1 |
Other References:
Andreas Geisser, Tatjana Hendrich, Gunther Boehm, Bernd Stahl,Separation of lactose from human milk oligosaccharides with simulated moving bed chromatography,Journal of Chromatography A,2005年,Vol. 1092,pp.17-23
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Yamaguchi
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Yamaguchi