To provide a method for presetting a printing unit of a printing machine for eliminating a regulating work when printed and capable of avoiding consumption of a material and improving a printing working efficiency by incorporating necessary sheet characteristics and accurately presetting a sheet guide of the unit.

In the printing machine comprising a printing unit for guiding sheets sent one by one from a feeder of a sheet supply unit by sheet guide provided at a lower part of an intermediate cylinder brought into rotary contact with an impression cylinder and printing by an ink received from a rubber cylinder on the impression cylinder while conveying the sheet, a preset set table for setting a preset amount of the guide based on sheet quality data including a type, a basis weight, a sheet size and a sheet texture of the sheet is formed, and a preset amount corresponding to an input value of the data is selected from the table.