Title:
METHOD FOR CATALYTICALLY ACTIVATING SILICATED NUCLEATING AGENT USING PHOSPHAZENE BASE
Document Type and Number:
Japanese Patent JP3864199
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for efficiently producing an intermediate for synthesizing a phosphazene base using an organic catalyst less harmful to the environment without using harmful heavy metals.
SOLUTION: H-Si, C-Si, O-Si and N-Si bonds of an organic silicated nucleating agent are activated by acting the phosphazene base to the organic silicated nucleating agent in an organic solvent. Substituted benzene derivatives and substituted aromatic hetero ring compounds which are intermediates for synthesizing medical products are synthesized by catalytically applying the mutual action to carry out nucleophilic substitution and nucleophilic addition reactions.
More Like This:
Inventors:
Yoshinori Neto
Masahiro Ueno
Masahiro Ueno
Application Number:
JP2005084904A
Publication Date:
December 27, 2006
Filing Date:
March 23, 2005
Export Citation:
Assignee:
Tohoku University
International Classes:
C07C1/32; C07C15/48; C07C29/38; C07C33/025; C07C33/042; C07C33/20; C07C41/02; C07C41/16; C07C43/23; C07C43/29; C07C67/31; C07C69/92; C07C201/12; C07C205/06; C07C205/38; C07C247/10; C07C253/30; C07C255/13; C07C255/36; C07C255/54; C07D277/64; C07D295/06; C07D307/80; C07D405/12; C07F7/18; C07B61/00
Domestic Patent References:
| JP3294254A | ||||
| JP63216827A |
Other References:
T.Imahori and Y.Kondo,A new strategy hor deprotonative functionalization of aromatics:,J. Am. Chem. Soc.,2003年,125,p.8082-8083
X.Du and R. W. Armstrong,Synthesis of bezofuran derivatives on solid support via SmI2-mediated radical cyclization,J. Org. Chem.,1997年,62,p.5678-5679
C. Palomo et al.,Fluoride-ion mediated reaction between trimethylsilylacetonitrile and carbonyl sompounds.,J. Chem. Soc. PERKIN TRANS. I,1989年,p.1692-1694
X.Du and R. W. Armstrong,Synthesis of bezofuran derivatives on solid support via SmI2-mediated radical cyclization,J. Org. Chem.,1997年,62,p.5678-5679
C. Palomo et al.,Fluoride-ion mediated reaction between trimethylsilylacetonitrile and carbonyl sompounds.,J. Chem. Soc. PERKIN TRANS. I,1989年,p.1692-1694
Attorney, Agent or Firm:
Kazuo Shigenobu
Mizuno Akinori
Hideo Shimizu
Yuichi Takagi
Yoshinao Nakano
Mizuno Akinori
Hideo Shimizu
Yuichi Takagi
Yoshinao Nakano
Previous Patent: CLEAN HOT CELL FOR SYNTHESIZING RADIOACTIVE MEDICINE, AND DISPOSITION STRUCTURE THEREFOR
Next Patent: INTERPOSER
Next Patent: INTERPOSER