METHOD AND COMPOSITION FOR ENHANCING VASCULAR ACCESS

Title:

METHOD AND COMPOSITION FOR ENHANCING VASCULAR ACCESS

Document Type and Number:

Japanese Patent JP2012166084

Kind Code:

A

Abstract:

To provide an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally.

The implantable material can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.

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Inventors:

NUGENT HELEN MARIE
EDELMAN ELAZER
ANUPAM DALAL
BOLLINGER STEVE
EPPERLY SCOTT

Application Number:

JP2012133043A

Publication Date:

September 06, 2012

Filing Date:

June 12, 2012

Export Citation:

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Assignee:

PERVASIS THERAPEUTICS INC

International Classes:

A61L27/00; A61F2/06; C12N5/07; C12N5/071

Domestic Patent References:

JPH03133901A	1991-06-07
JPH0646840A	1994-02-22
JP2000507547A	2000-06-20

Foreign References:

WO2001095717A2	2001-12-20
WO2001070021A1	2001-09-27

Other References:

NATHAN,A. ET AL.: "Tissue engineered perivascular endothelial cell implants regulate vascular injury.", PROC. NATL. ACAD. SCI. USA, vol. 92, no. 18, JPN6013017931, 29 August 1995 (1995-08-29), pages 8130 - 4, XP055000095, ISSN: 0002871192, DOI: 10.1073/pnas.92.18.8130

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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