METHOD AND COMPOSITION FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS

Title:

METHOD AND COMPOSITION FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS

Document Type and Number:

Japanese Patent JP2009112319

Kind Code:

A

Abstract:

To provide a method for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups.

Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7430 Ester Hydrolase also are provided. In one embodiment, this invention comprises following steps: (a) identifying a non-nucleotide prototype compound, (b) substituting the prototype compound with phosphonate-containing group to form a candidate compound, and (c) determining the anti-HIV activity of the candidate compound.

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Inventors:

BIRKUS GABRIEL
CHEN JAMES M
CHEN XIAOWU
TOMAS CIHLAR
EISENBERG EUGENE J
MARCOS HATADA
HE GONG-XIN
KIM CHOUNG U
LEE WILLIAM A
MARTIN J MCDERMOTT
SWAMINATHAN SUNDARAMOORTHI

Application Number:

JP2009052719A

Publication Date:

May 28, 2009

Filing Date:

March 05, 2009

Export Citation:

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Assignee:

GILEAD SCIENCES INC

International Classes:

C12N9/99; C12Q1/44; A61K31/4155; A61K31/66; A61K31/665; A61K31/675; A61P31/18; A61P43/00; C07D213/75; C07D213/85; C07D231/12; C07D231/20; C07D233/42; C07D239/48; C07D239/80; C07D243/04; C07D265/18; C07D307/68; C07D401/06; C07D403/06; C07D471/14; C07D491/04; C07F9/02; C07F9/38; C07F9/40; C07F9/44; C07F9/58; C07F9/62; C07F9/645; C07F9/6506; C07F9/6509; C07F9/6512; C07F9/653; C07F9/6533; C07F9/655; C07F9/6558; C07F9/6561; C07F9/6584; C12N9/16; C12Q1/02; C12Q1/18; C12Q1/37; C12Q1/70; G01N33/04; G01N33/50; C07F

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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