To control the pyruvic acid metabolism pathway of a microorganism, in association with the method for controlling the metabolism pathway of the microorganism.
The metabolism of the microorganism, having a starting point of pyruvic acid is controlled by making an electrode in contact with a culturing environment comprising the microorganism producing metabolites from the pyruvic acid, and culturing while controlling the potential of the electrode. More specifically, the method is provided by using the microorganism having the metabolism pathways having a reducing pathway of reducing the pyruvic acid to lactic acid and an oxidation pathway of oxidizing the pyruvic acid to an acetyl coenzyme (A), as a controlling objective microorganism, making the electrode in contact with the culturing environment containing the microorganism, and by culturing the microorganisms while controlling the potential of the electrode to the reducing potential to prompt the reducing reaction in the reducing pathway and to decrease the oxidation reaction in the oxidizing pathways. Oppositely, by culturing while controlling the potential of the electrode to the oxidizing potential, the reducing reaction in the reducing pathway is decreased and the oxidation reaction in the oxidizing pathway is prompted.
MATSUMOTO TAKAO
OMURA NAOYA
| JP2008054646A | 2008-03-13 | |||
| JP2009178145A | 2009-08-13 |
JPN6015014912; ＲＩＯＮＤＥＴ， Ｃ．， ｅｔ ａｌ．: ＪＯＵＲＮＡＬ ＯＦ ＢＡＣＴＥＲＩＯＬＯＧＹ Ｖｏｌ．１８２， Ｎｏ．３, 200002, ｐｐ．６２０-６２６
JPN7015001015; 平野伸一ら: '電気を用いた革新的微生物変換技術の開発（その１） -物質生産に向けた大腸菌の電気培養-' 電力中央研究所報告 研究報告：Ｖ０９０２６, 201009
JPN6015014918; 平野伸一ら: 第６２回日本生物工学会大会講演要旨集 , 20100925, ｐ．１２９（要旨番号２Ｐ-２１４４）
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