Title:
METHOD FOR DECREASING SERUM CHORESTEROL
Document Type and Number:
Japanese Patent JPH08225446
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To obtain a pharmaceutical, containing a compound having a specific structure as an active ingredient and capable of lowering serum cholesterol. SOLUTION: This pharmaceutical comprises a compound represented by the formula [R<1> is H or a bivalent moiety which distances L from the ring B by 6-8 intervening atoms; R<2> is H, a 1-5C straight chain or branched chain (un)saturated chain, etc.; R<3> is absent or a (un)substituted bivalent moiety, etc., which join R<2> and L to form a 5- to a 7-membered heterocyclic ring; R<4> is H or a lower alkyl; R<5> and R<6> are each H, hydroxy, etc.; L is -CON< or -N<; the dotted line in the B ring is an optional bond] or its salt and, as necessary, an estrogen. A compound in which L is -N< and R<2> joins R<3> and L to form piperidino is preferred as the compound represented by the formula. The compound represented by the formula is preferably administered in 50-600 mg daily dose to a human in one to three divided portions. The daily dose of the estrogen is preferably 0.1-2 mg administered in one to three divided portions.
Inventors:
TEIMOSHII ARAN GURIISU
Application Number:
JP29978795A
Publication Date:
September 03, 1996
Filing Date:
November 17, 1995
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
C07D335/06; A61K31/135; A61K31/165; A61K31/18; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/445; A61K31/47; A61K31/472; A61K31/565; A61P3/06; C07D215/12; C07D217/12; C07D311/34; (IPC1-7): A61K31/135; A61K31/165; A61K31/18; A61K31/35; A61K31/38; A61K31/47; A61K31/565; C07D335/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)