METHOD OF DECREASING TISSUE INJURY RELATING TO NON-CARDIAC ISCHEMIA BY USING GLYCOGEN-PHOSPHORYLASE INHIBITOR

Title:

METHOD OF DECREASING TISSUE INJURY RELATING TO NON-CARDIAC ISCHEMIA BY USING GLYCOGEN-PHOSPHORYLASE INHIBITOR

Document Type and Number:

Japanese Patent JP3277147

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To make it possible to decrease the non-cardiac tissue injury caused by ischemia and/or low oxygen, particularly the ischemic injury in diabetes, by administrating a glycogen-phosphorylase inhibitor.
SOLUTION: The glycogen-phosphorylase inhibitor of the formula [the dotted line is an optional bond; A is -C(CH)=,-C (an 1-4C alkyl)=, methylene, etc.; R1, R10 and R11 are each H, a halogeno, cyano, an alkyl etc.; R2 is H; R3 is H and an alkyl; R4 is H, methyl, a heterocyclic ring, etc.; R5 is H, hydroxy, etc., R6 is carboxy and the like; R7 is H, fluoro, etc.; R8 is H, an alkyl, etc.; R9 is a substituted alkyl and the like] is administrated in an amount of 0.1-100 mg/kg/day This inhibitor is useful for reducing or minimizing the injury which affects directly tissues such as brain, lung, kidney, liver, intestine, skeletal muscle, pancreas, blood vessel system and rentina sensitive to the ischemia- reperfusion injury in arterial embolism and the like.

Inventors:

Dennis Jay Hoover
William Holt Martin
Wayne Ross Tracy
Judith Lee Treadway

Application Number:

JP33252397A

Publication Date:

April 22, 2002

Filing Date:

December 03, 1997

Export Citation:

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Assignee:

Pfizer Inc.

International Classes:

A61K31/00; A61K31/40; A61K31/403; A61K31/404; A61K31/42; A61K31/423; A61K31/427; A61K31/445; A61K31/454; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P9/00; A61P9/10; A61K45/00; A61P13/00; A61P19/00; A61P25/00; A61P27/02; A61P43/00; C07D209/42; (IPC1-7): A61K45/00; A61K31/404; A61K31/423; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P9/00; A61P13/00; A61P19/00; A61P25/00; A61P27/02; A61P43/00

Other References:

【文献】国際公開96/39385(WO,A1)
【文献】国際公開96/39384(WO,A1)

Attorney, Agent or Firm:

Kazuo Shamoto (5 outside)

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