Title:
METHOD FOR DETECTION OF ALTERATIONS IN DNA MISMATCH REPAIR PATHWAY
Document Type and Number:
Japanese Patent JP2007312783
Kind Code:
A
Abstract:
To provide an eukaryotic DNA mismatch repair pathway, the genes involved, and uses thereof, for example, in drug screening, cancer prognosis and diagnosis.
A method of determining whether there is an alteration in a human DNA mismatch repair pathway which comprises: (a) isolating a biological specimen from a preliminarily selected eucaryote; (b) testing the specimen for an alteration in a DNA mismatch repair pathway nucleotide sequence or its expression product; and (c) comparing the results obtained in step (b) with the results obtained from a wild type control.
COPYRIGHT: (C)2008,JPO&INPIT
Inventors:
KOLODNER RICHARD D
FISHEL RICHARD
REENAN ROBERT A G
FISHEL RICHARD
REENAN ROBERT A G
Application Number:
JP2007185089A
Publication Date:
December 06, 2007
Filing Date:
July 13, 2007
Export Citation:
Assignee:
DANA FARBER CANCER INST INC
UNIV OF VERMONT & STATE AGRICU
UNIV OF VERMONT & STATE AGRICU
International Classes:
A01K67/027; C12Q1/68; A61K38/00; A61P1/00; A61P13/02; A61P15/00; A61P35/00; C07H21/04; C07K14/47; C12N15/09; C12P21/02; C12R1/865
Domestic Patent References:
| JPH09506509A | 1997-06-30 | |||
| JPH09506509A | 1997-06-30 |
Other References:
JPN6009067797, Ｇｅｎｅｔｉｃｓ，１９９２年１２月，１３２，９６３−９７３
JPN6009067794, Ｎａｔｕｒｅ，１９９３年 ９月，３６５，２７４−２７６
JPN6009067795, Ｃｅｌｌ ７５ ｐ．１０２７−１０３８ （１９９３．１２．０３）
JPN6009067796, Ｃｅｌｌ ７５ ｐ．１２１５−１２２５ （１９９３．１２．１７）
JPN6009067794, Ｎａｔｕｒｅ，１９９３年 ９月，３６５，２７４−２７６
JPN6009067795, Ｃｅｌｌ ７５ ｐ．１０２７−１０３８ （１９９３．１２．０３）
JPN6009067796, Ｃｅｌｌ ７５ ｐ．１２１５−１２２５ （１９９３．１２．１７）
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita