Title:
イオントラップ質量分析器を用いてサンプルイオンの質量分析を実施するためのパラメータを判定するための方法
Document Type and Number:
Japanese Patent JP7125522
Kind Code:
B2
Abstract:
A method for determining a parameter for controlling an amount of sample ions ionised from a sample, which is injected from an ion storage unit into an ion trapping mass analyser to perform a mass analysis of the sample ions. The method comprises the steps:• detecting at least one mass spectrum for at least one amount of the sample ions injected from the ion storage unit with the ion trapping mass analyser;• determining from the at least one detected mass spectrum the sample slope of a linear correlation of the relative m/z shift with the visible total charge Qv of mass spectra of sample ions detected with the ion trapping mass analyser;• determining a compensation factor c to adjust an ion injection time period topt,v of sample ions into the ion storage unit, which is related to the optimised visible charge Qref,opt of a reference sample, to perform a mass analysis of sample ions, wherein the ion injection time period topt,v is determined from the visible total charge Qv evaluated from at least one mass spectrum of at least one amount of the sample ions detected with the ion trapping mass analyser and the corresponding injection time period of the sample ions, by dividing the reference slope of a linear correlation of the relative m/z shift with the visible total charge Qv of mass spectra of reference ions ionised from the reference sample, detected with the ion trapping mass analyser by the determined sample slope.
Inventors:
Oliver Lange
Application Number:
JP2021038153A
Publication Date:
August 24, 2022
Filing Date:
March 10, 2021
Export Citation:
Assignee:
Thermo Fisher Scientific (Bremen) Gamem Beher
International Classes:
H01J49/00; G01N27/62; H01J49/38; H01J49/42
Domestic Patent References:
| JP2014519603A | ||||
| JP2008544472A | ||||
| JP2006517723A | ||||
| JP2013007637A |
Foreign References:
| US20070203652 | ||||
| US20140061460 | ||||
| US20080203293 | ||||
| US20040217272 | ||||
| US20120326027 |
Attorney, Agent or Firm:
Shinichiro Tanaka
Yoshi Kazuhiko Ta
Hiroyuki Suda
Matsushita Mitsuru
Ichiro Kurasawa
Yasushi Yamamoto
Hiroko Suzuki
Ryo Ishizaki
Yoshi Kazuhiko Ta
Hiroyuki Suda
Matsushita Mitsuru
Ichiro Kurasawa
Yasushi Yamamoto
Hiroko Suzuki
Ryo Ishizaki
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