Title:
METHOD OF ESTIMATING SENSITIVITY TO OSTEOPOROSIS REMEDY AND REAGENT KIT THEREFOR
Document Type and Number:
Japanese Patent JP3682688
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method of estimating sensitivity to osteoporosis remedies, capable of estimating which one among plural osteoporosis remedies is most effective for an object patient, before the remedy is administered, so that the remedy can be suitably chosen, and therefore extremely useful for improving QOL(quality of life) of the patient.
SOLUTION: This method of estimating sensitivity to the osteoporosis remedies comprises analyzing genomic DNA contained in a sample derived from a human for each polymorphism of the vitamin D receptor gene, the estrogen receptor gene, and the apolipoprotein E3 gene, then estimating based on the analyzed gene polymorphism combination that the analyzed sample is derived from such a person as the person's sensitivity to a specific remedy has priority over those to the other remedies among the plural osteoporosis remedies.
Inventors:
Masataka Shiraki
Ouchi
Takayuki Hosoi
Ouchi
Takayuki Hosoi
Application Number:
JP2000155993A
Publication Date:
August 10, 2005
Filing Date:
May 26, 2000
Export Citation:
Assignee:
NIPRO CORPORATION
International Classes:
G01N33/53; A61K31/122; A61K31/56; A61K31/59; A61P19/10; C12N15/09; C12Q1/68; G01N33/566; (IPC1-7): C12Q1/68; A61K31/122; A61K31/56; A61K31/59; A61P19/10; C12N15/09
Domestic Patent References:
| JP2000350600A | ||||
| JP2001029088A | ||||
| JP8501933A | ||||
| JP9511138A | ||||
| JP2000300295A | ||||
| JP2000155871A |
Other References:
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第15回骨代謝学会プログラム抄録集,1997年,p.52
遺伝子医学,1988年,2(2),259-62
Hum Genet,1998年,103,576-85
Calcif Tissue Int,1998年,62,278-81
Proceedings of the Society for Experimental Biology and Medicine,1996年,212(2),110-5
Journal of Bone and Mineral Research,1997年,12(9),1438-45
Journal of Bone and Mineral Research,1996年,11(3),306-11
Nature,1994年,367,284-7
厚生省厚生科学研究費補助金 長寿化科学総合研究 平成8年度研究報告,1997年,6,290-2
医学と薬学,2001年,45(5),931-22
基礎老化研究,2001年,25(3),138-41
第15回骨代謝学会プログラム抄録集,1997年,p.52
遺伝子医学,1988年,2(2),259-62
Hum Genet,1998年,103,576-85
Calcif Tissue Int,1998年,62,278-81
Proceedings of the Society for Experimental Biology and Medicine,1996年,212(2),110-5
Journal of Bone and Mineral Research,1997年,12(9),1438-45
Journal of Bone and Mineral Research,1996年,11(3),306-11
Nature,1994年,367,284-7
厚生省厚生科学研究費補助金 長寿化科学総合研究 平成8年度研究報告,1997年,6,290-2
医学と薬学,2001年,45(5),931-22
基礎老化研究,2001年,25(3),138-41
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