Title:
METHOD FOR EVALUATION OF ANTICANCER AGENT BASED ON GSK3 BETA INHIBITORY EFFECT
Document Type and Number:
Japanese Patent JP2012187105
Kind Code:
A
Abstract:
To provide a novel means for cancer treatment/diagnosis by elucidating involvement of glycogenesis enzyme kinase 3β (GSK3β) in survival and proliferation of cancer cells.
The method evaluates the effect of a test article as an anticancer agent with the inhibitory effect against the activity of the enzyme activated via phosphorylation of the 216th tyrosine residue of glycogenesis enzyme kinase 3β (GSK3β) as an indicator.
Inventors:
MINAMOTO TOSHISHIGE
Application Number:
JP2012091933A
Publication Date:
October 04, 2012
Filing Date:
April 13, 2012
Export Citation:
Assignee:
UNIV KANAZAWA
International Classes:
C12Q1/48; C12N15/09; G01N33/15; G01N33/50; G01N33/574; A01K67/027; C12N9/12; C12N9/99
Other References:
JPN6013049012; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ , 2004, ｐｐ．４１１-４１５, Ｖｏｌ． ３１６
JPN6013049009; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ． ３３４, 2005, ｐｐ．１３６５-１３７３
JPN6013049010; Ｅｎｄｏｃｒｉｎｏｌｏｇｙ Ｖｏｌ． １４５， Ｎｏ． ６, 2004, ｐｐ．２９４１-２９４９
JPN6013049011; Ｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｌｏｇｙ Ｖｏｌ． １０, 2003, ｐｐ．１２５５-１２６６
JPN6013049009; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ． ３３４, 2005, ｐｐ．１３６５-１３７３
JPN6013049010; Ｅｎｄｏｃｒｉｎｏｌｏｇｙ Ｖｏｌ． １４５， Ｎｏ． ６, 2004, ｐｐ．２９４１-２９４９
JPN6013049011; Ｃｈｅｍｉｓｔｒｙ ａｎｄ Ｂｉｏｌｏｇｙ Ｖｏｌ． １０, 2003, ｐｐ．１２５５-１２６６
Attorney, Agent or Firm:
島村 直己
平木 祐輔
藤田 節
平木 祐輔
藤田 節
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