Title:
レンチウイルスベクター由来の組換えタンパク質を発現させる方法
Document Type and Number:
Japanese Patent JP2009502134
Kind Code:
A
Abstract:
Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.
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Inventors:
Fan, chen min
Joss, Carlin
Simmons, Andrew Dee.
Pherson, Deborah A.
Chen, Chin Chin
Joss, Carlin
Simmons, Andrew Dee.
Pherson, Deborah A.
Chen, Chin Chin
Application Number:
JP2008522913A
Publication Date:
January 29, 2009
Filing Date:
July 19, 2006
Export Citation:
Assignee:
Cell Genesis, Inc.
International Classes:
C12N15/09; C07K16/18; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita