分子マーカーを用いた間葉系幹細胞の識別方法及びその利用

Japanese Patent JP5190654

B2

Disclosed is a method for distinguishing a mesenchymal stem cell comprising, using at least one gene selected from the genes having the nucleotide sequences indicated by the accession numbers shown in Table 1 as a distinguish marker, detecting the difference in expression of the distinguish marker between a mesenchymal stem cell and a connective tissue cell to distinguish the mesenchymal stem cell from the connective tissue cell. This method enables to distinguish an undifferentiated mesenchymal stem cell from other connective tissue cell such as fibroblasts, osteoblasts, chondrocytes and adipose cells with good accuracy. A mesenchymal stem cell given by this method or a composition comprising the mesenchymal stem sell can be used as a therapeutic for use in the regenerative medicine.

JPWO2008075501	Rotary extractor, cell type identification method using it, gene detection method, and automatic nucleic acid extractor
JP3813818	Method for determining nucleotide sequences of oligonucleotides and DNA molecules
WO/2000/075647	SYSTEM AND METHOD FOR PRENATAL DIAGNOSTIC SCREENING

Yukio Kato
Ken Kawamoto
Koichiro Tsuji
Akira Igarashi
Masakazu Shimizu

JP2007512850A

April 24, 2013

March 30, 2006

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Hiroshima University
Tucell Corporation

C12Q1/68; C12N5/077; C12N5/0775; C12N15/09; C12Q1/6881

JP2004290189A	2004-10-21
JP2005027579A	2005-02-03

JPN6011036696; 再生医療 Ｖｏｌ．４，　増刊号, 20050210, ｐ．１１５，　ＰＤ-２４
JPN6011036700; Ｇｅｎｅ Ｖｏｌ．３４０, 2004, ｐ．１４１-１５０
JPN6011036710; Ｂｏｎｅ Ｖｏｌ．３４, 2004, ｐ．８０９-８１７
JPN6011036712; Ｏｓｔｅｏａｒｔｈｒｉｔｉｓ　Ｃａｒｔｉｌａｇｅ Ｖｏｌ．８, 2000, ｐ．８７-９５
JPN6012057222; Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ Ｖｏｌ．１０１，　Ｎｏ．９, 2004, ｐ．２９５７-２９６２

Kenzo Hara International Patent Office

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