METHOD FOR INHIBITING ULTRAVIOLET-INDUCED APOPTOSIS

Japanese Patent JP2005272343

A

To provide a new and effective UV(ultraviolet)-defensive means through elucidating a new epidermis-specific UV-defensive mechanism.

A method for enhancing the resistance to dermatic disorder onset attributable to ultraviolet irradiation on the skin by advancing the expression in SCCA-1/-2 of epidermal cell to inhibit ultraviolet-induced apoptosis is provided. Further, a skin inspection method for rating the resistance to dermatic disorder attributable to ultraviolet irradiation on the skin is also provided, comprising assaying the expression of SCCA-1/-2 in epidermal cell and, when the expression declines compared with that in the epidermal cell, judging that the UV resistance of the epidermis is low. Besides, a method for screening a drug enhancing the resistance to dermatic disorder attributable to ultraviolet irradiation on the skin is also provided, comprising selecting a drug that advances the expression of SCCA-1 and/or -2 as an UV resistance enhancer.

KATAGIRI CHIKA
HIBINO TOSHIHIKO

JP2004087051A

October 06, 2005

March 24, 2004

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SHISEIDO CO LTD

G01N33/50; A61K8/00; A61K8/14; A61K8/60; A61K8/64; A61K31/7088; A61K38/00; A61K45/00; A61K48/00; A61P17/00; A61P17/16; A61P29/00; A61P43/00; A61Q17/04; A61Q19/00; C07K14/47; C12N15/09; C12Q1/68; G01N33/15; G01N33/53; G01N33/68; (IPC1-7): A61K45/00; A61K7/48; A61P17/00; A61P17/16; A61P29/00; A61P43/00; C12Q1/68; G01N33/15; G01N33/50; G01N33/53

Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama

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