METHOD OF INHIBITING WNT SIGNAL TRANSDUCTION USING AT LEAST EITHER OF NON-SYMMETRIC OPTICALLY ACTIVE BISINDOLE COMPOUND AND SALT THEREOF, AND WNT SIGNAL TRANSDUCTION INHIBITING AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT

Title:

Document Type and Number:

Japanese Patent JP2014162731

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To create a novel Wnt/β-catenin signal transduction inhibiting agent.SOLUTION: A Wnt signal transduction inhibiting agent comprises an optically active non-symmetric bisindole represented by the formula (1) as an active ingredient. In the formula, Rand Rcan be each independently H, Me, Et, Bn, Ts, Ms, Ac, Bz, MOM, MEM, SEM or Alloc. X and Y can be each independently H, Me, Et, Bn, halogen, alkoxy, amino, an acyl group or a nitro group. X and Y may be plurally bonded to any positions on the benzene ring of indole or an oxindole skeleton.

Inventors:

ARAI TAKAYOSHI
ARAI MIDORI
ISHIBASHI MASAMI
YAMAMOTO YUJI
KAMIYA KENTARO
AWADA ATSUKO

Application Number:

JP2013032667A

Publication Date:

September 08, 2014

Filing Date:

February 21, 2013

Export Citation:

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Assignee:

UNIV CHIBA

International Classes:

A61K31/404; A61P3/10; A61P25/28; A61P35/00; A61P43/00

Domestic Patent References:

JP2013142080A	2013-07-22
JP2013142080A	2013-07-22

Other References:

JPN7016003613; 第一三共生命化学研究振興財団研究報告集Ｖｏｌ．２９, 2013, ｐ．３-１２
JPN7016003614; Ａｄｖ　Ｓｙｎｔｈ　ＣａｔａｌＶｏｌ．３５５, 2013, ｐ．２５３１-２５３７
JPN7016003615; Ｂｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　ＬｅｔｔｅｒｓＶｏｌ．１７, 2007, ｐ．４２５４-４２５７
JPN7016003613; 第一三共生命科学研究振興財団研究報告集Ｖｏｌ．２９, 2013, ｐ．３-１２
JPN7016003614; Ａｄｖ　Ｓｙｎｔｈ　ＣａｔａｌＶｏｌ．３５５, 2013, ｐ．２５３１-２５３７
JPN7016003615; Ｂｉｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　ＬｅｔｔｅｒｓＶｏｌ．１７, 2007, ｐ．４２５４-４２５７

Attorney, Agent or Firm:

Masayoshi Takahashi

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