Title:
METHOD OF ISOLATING AND PURIFYING ANTIBIOTIC
Document Type and Number:
Japanese Patent JPS6011423
Kind Code:
A
Abstract:
A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0 DEG to 40 DEG C. and at a pressure which lies between the critical pressure and the ten-fold value of the critical pressure of the extraction agent, with the weight ratio of antibiotic containing solution to the extraction agent being 1:5 to 1:20, wherein the antibiotics are precipitated from the antibiotic containing extraction agent by reducing its density and wherein the extraction agent is recirculated. An entrainer may be added to the extraction agent. The reduction in density of the antibiotic containing extraction agent may be effected by expansion to a pressure of from 30 to 70 bar.
Inventors:
FUUBERUTO KEENEN
RAINAA HAAGEN
JIIKUFURIIDO PEETAA
RAINAA HAAGEN
JIIKUFURIIDO PEETAA
Application Number:
JP9767284A
Publication Date:
January 21, 1985
Filing Date:
May 17, 1984
Export Citation:
Assignee:
KRUPP GMBH
International Classes:
A61K35/74; A61K38/00; B01D11/04; C07C69/675; C07D307/94; C07D499/00; C07D499/18; C07D501/12; C07K1/14; C12P37/00; (IPC1-7): A61K35/74; A61K37/00; B01D11/04; C07D307/94; C07D499/18; C12P37/00
Attorney, Agent or Firm:
Toshio Yano