Title:
METHOD FOR ISOMERIZING 6β-FLUOROSTEROIDS INTO CORRESPONDING 6α-FLUORO DERIVATIVES
Document Type and Number:
Japanese Patent JP2002155097
Kind Code:
A
Abstract:
To convert a 6β-fluorosteroid into a corresponding pharmacologically active 6α-fluoro derivative without requiring vigorous reaction conditions.
This method for isomerizing a 6β-fluoro derivative into a corresponding 6α-fluoro derivative of a pregnane compound represented by general formula (I) comprises the reaction of a 6β-fluorosteroid or a 6α/6β-isomeric mixture with an organic base to give a 6α/6' mixture rich in 6α, having a 6α/6β ratio higher than 95:5. The organic base contains a diazoimino group and the reaction is carried out in an aprotic polar organic solvent.
Inventors:
CAINELLI GIANFRANCO
UMANI-RONCHI ACHILLE
CONTENTO MICHELE
SANDRI SERGIO
DA COL MARCO
UMANI-RONCHI ACHILLE
CONTENTO MICHELE
SANDRI SERGIO
DA COL MARCO
Application Number:
JP2001148749A
Publication Date:
May 28, 2002
Filing Date:
May 18, 2001
Export Citation:
Assignee:
FARMABIOS SRL
International Classes:
C07B55/00; C07B61/00; C07J5/00; C07J71/00; (IPC1-7): C07J5/00
Attorney, Agent or Firm:
Toshio Shiozawa (2 outside)
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