Title:
METHOD AND KIT FOR DETECTING PROLIFERATIVE DISEASE CAUSING SCLEROSIS, PREVENTIVE AND/OR REMEDY FOR PROLIFERATIVE DISEASE CAUSING SCLEROSIS, AND METHOD AND KIT FOR IDENTIFYING SUBSTANCE EFFICACIOUS IN PREVENTING AND/OR TREATING PROLIFERATIVE DISEASE CAUSING SCLEROSIS
Document Type and Number:
Japanese Patent JP2011050383
Kind Code:
A
Abstract:
To provide a method and a kit for detecting proliferative diseases causing sclerosis, to provide a preventive and/or a remedy for proliferative diseases causing sclerosis, and to provide a method and a kit for identifying a substance efficacious in preventing and/or treating proliferative diseases causing sclerosis.
There are provide a detection method for diabetic nephropathy, comprising measuring the expression of at least one substance selected from the group consisting of activin receptor-like kinase 1, activin receptor-like kinase 3 and bone morphogenetic proteins, in a biological sample. A kit therefor is also provided.
Inventors:
DOI TOSHIO
ABE SHUSEI
ABE SHUSEI
Application Number:
JP2010218011A
Publication Date:
March 17, 2011
Filing Date:
September 29, 2010
Export Citation:
Assignee:
HUBIT GENOMIX INC
DOI TOSHIO
CHUGAI PHARMACEUTICAL CO LTD
DOI TOSHIO
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C12Q1/68; A61K45/06; A61P13/12; A61P43/00; C12N15/09; C12Q1/48; G01N33/68
Domestic Patent References:
| JP4664815B2 | 2011-04-06 | |||
| JP4664815B2 | 2011-04-06 |
Other References:
JPN6010020162; Ｊｏｕｒｎａｌ ｏｆ ｃｅｌｌｕｌａｒ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２００１， Ｖｏｌ．８１， Ｎｏ．１， ｐ．１０２-１１３
JPN6010020168; Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ． １９９４， Ｖｏｌ．９１， Ｎｏ．２０
JPN6010020172; Ｅｕｒｏｐｅａｎ ｊｏｕｒｎａｌ ｏｆ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２０００， Ｖｏｌ．２６７， Ｎｏ．２４， ｐ．６９５４-６９６７
JPN6010020175; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ ｂｉｏｌｏｇｉｃａｌ ｃｈｅｍｉｓｔｒｙ． ２００４ Ａｐｒ（Ｅｐｕｂ ２００４ Ｊａｎ）， Ｖｏｌ．２７９， Ｎｏ．１４， ｐ．１４２０１-１４２０６
JPN6010020177; Ｔｈｅ ＥＭＢＯ ｊｏｕｒｎａｌ． ２０００， Ｖｏｌ．１９， Ｎｏ．８， ｐ．１７４５-１７５４
JPN6010020165; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｓｏｃｉｅｔｙ ｏｆ Ｎｅｐｈｒｏｌｏｇｙ． ２００１， Ｖｏｌ．１２， Ｎｏ．１１， ｐ．２３９２-２３９９
JPN6010020165; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｓｏｃｉｅｔｙ ｏｆ Ｎｅｐｈｒｏｌｏｇｙ． ２００１， Ｖｏｌ．１２， Ｎｏ．１１， ｐ．２３９２-２３９９
JPN6010020162; Ｊｏｕｒｎａｌ ｏｆ ｃｅｌｌｕｌａｒ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２００１， Ｖｏｌ．８１， Ｎｏ．１， ｐ．１０２-１１３
JPN6010020168; Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ． １９９４， Ｖｏｌ．９１， Ｎｏ．２０
JPN6010020172; Ｅｕｒｏｐｅａｎ ｊｏｕｒｎａｌ ｏｆ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２０００， Ｖｏｌ．２６７， Ｎｏ．２４， ｐ．６９５４-６９６７
JPN6010020175; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ ｂｉｏｌｏｇｉｃａｌ ｃｈｅｍｉｓｔｒｙ． ２００４ Ａｐｒ（Ｅｐｕｂ ２００４ Ｊａｎ）， Ｖｏｌ．２７９， Ｎｏ．１４， ｐ．１４２０１-１４２０６
JPN6010020177; Ｔｈｅ ＥＭＢＯ ｊｏｕｒｎａｌ． ２０００， Ｖｏｌ．１９， Ｎｏ．８， ｐ．１７４５-１７５４
JPN6010020168; Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ． １９９４， Ｖｏｌ．９１， Ｎｏ．２０
JPN6010020172; Ｅｕｒｏｐｅａｎ ｊｏｕｒｎａｌ ｏｆ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２０００， Ｖｏｌ．２６７， Ｎｏ．２４， ｐ．６９５４-６９６７
JPN6010020175; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ ｂｉｏｌｏｇｉｃａｌ ｃｈｅｍｉｓｔｒｙ． ２００４ Ａｐｒ（Ｅｐｕｂ ２００４ Ｊａｎ）， Ｖｏｌ．２７９， Ｎｏ．１４， ｐ．１４２０１-１４２０６
JPN6010020177; Ｔｈｅ ＥＭＢＯ ｊｏｕｒｎａｌ． ２０００， Ｖｏｌ．１９， Ｎｏ．８， ｐ．１７４５-１７５４
JPN6010020165; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｓｏｃｉｅｔｙ ｏｆ Ｎｅｐｈｒｏｌｏｇｙ． ２００１， Ｖｏｌ．１２， Ｎｏ．１１， ｐ．２３９２-２３９９
JPN6010020165; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｓｏｃｉｅｔｙ ｏｆ Ｎｅｐｈｒｏｌｏｇｙ． ２００１， Ｖｏｌ．１２， Ｎｏ．１１， ｐ．２３９２-２３９９
JPN6010020162; Ｊｏｕｒｎａｌ ｏｆ ｃｅｌｌｕｌａｒ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２００１， Ｖｏｌ．８１， Ｎｏ．１， ｐ．１０２-１１３
JPN6010020168; Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ． １９９４， Ｖｏｌ．９１， Ｎｏ．２０
JPN6010020172; Ｅｕｒｏｐｅａｎ ｊｏｕｒｎａｌ ｏｆ ｂｉｏｃｈｅｍｉｓｔｒｙ． ２０００， Ｖｏｌ．２６７， Ｎｏ．２４， ｐ．６９５４-６９６７
JPN6010020175; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ ｂｉｏｌｏｇｉｃａｌ ｃｈｅｍｉｓｔｒｙ． ２００４ Ａｐｒ（Ｅｐｕｂ ２００４ Ｊａｎ）， Ｖｏｌ．２７９， Ｎｏ．１４， ｐ．１４２０１-１４２０６
JPN6010020177; Ｔｈｅ ＥＭＢＯ ｊｏｕｒｎａｌ． ２０００， Ｖｏｌ．１９， Ｎｏ．８， ｐ．１７４５-１７５４
Attorney, Agent or Firm:
Setuko Mayama
Kenichi Nomura
Kenichi Nomura
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