Title:
METHOD FOR MAKING TARGETED THERAPEUTIC AGENT
Document Type and Number:
Japanese Patent JP2017061564
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method and kit for making a targeted therapeutic agent for treating a disease or condition.SOLUTION: The present invention provides a method for making a targeted therapeutic agent. The method comprises the steps of: obtaining a biological sample from a patient having the disease or condition, or who is at risk for developing the disease or condition, the biological sample including a population of diseased cells; screening a library comprising proteins linked to their cognate mRNAs to identify mRNA-protein pairs that bind to the diseased cells to isolate one or more proteins from the identified mRNA-protein pairs; and conjugating the isolated protein(s) to a therapeutic agent.SELECTED DRAWING: Figure 4
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Inventors:
WILLIAMS RICHARD B
Application Number:
JP2016243972A
Publication Date:
March 30, 2017
Filing Date:
December 16, 2016
Export Citation:
Assignee:
PROTEONOVA INC
International Classes:
A61K47/50; A61K38/00; A61K39/395; A61K47/42; A61P35/00; A61P35/02; C07K19/00
Foreign References:
| US4661347A | 1987-04-28 |
Other References:
REITER Y, ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 142, no. 8, JPN6015051195, 1989, pages 2771 - 2777
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata