To provide a method capable of manufacturing an α,α-difluoro aromatic compound (a CF2 group directly bonds to an aromatic ring) in which high yield cannot be expected, industrially at low cost, in good yield, without requiring a high toxic catalyst, with simple operation, and with the use of a simple reactor.
A method of manufacturing an α,α-difluoro aromatic compound includes a process to make 1-chloro-1-aromatic ring substitution ethenes react with " a salt or complex consisting of an organic base and hydrogen fluoride". 1-chloro-1-aromatic ring substitution ethenes and "the salt or complex consisting of an organic base and hydrogen fluoride" can be obtained at comparatively low cost and at a large-amount scale. Moreover, an adopted reaction condition is mild, thereby selectivity is high and yield is also excellent. Further, a high toxic catalyst is not needed, a reactor is simple, and operation is also convenient. The present invention is very useful in this manner as an industrial manufacturing method of the α,α-difluoro aromatic compound.
YAMAZAKI TAKAKO
NISHINOMIYA TAKAYUKI
WATANABE MINEO
| JP2012067037A | 2012-04-05 | |||
| JP2006290870A | 2006-10-26 | |||
| JP2002322101A | 2002-11-08 | |||
| JP2000509064A | 2000-07-18 | |||
| JP2004537502A | 2004-12-16 | |||
| JP2012067037A | 2012-04-05 | |||
| JP2006290870A | 2006-10-26 | |||
| JP2002322101A | 2002-11-08 | |||
| JP2000509064A | 2000-07-18 |