Title:
METHOD OF MANUFACTURING NOVEL SUBSTITUTED NN*11*3*44METHYLENEDIOXYPHENYL**PROPYL*2***N**SUBSTITUTED PHENYLPIPERAZINES
Document Type and Number:
Japanese Patent JPS52287
Kind Code:
A
Abstract:
1521052 Pharmaceutical compositions BOEHRINGER INGELHEIM GmbH 2 Sept 1975 [3 Sept 1974] 03218/78 Divided out of 1521051 Heading A5B Pharmaceutical compositions in the form of dosage units useful in reducing the blood lipid level and the blood cholesterol level comprise as active ingredient N-[1-(3', 4'- methylenedioxyphenyl) - prop - 2 - yl] - N' - (2- chloro-phenyl)-piperazine or a physiologically compatible acid addition salt thereof in association with a pharmaceutical carrier or excipient, each dosage unit containing greater than 40 mg, but no greater than 60 mg of active ingredient. The compositions may further contain a coronary dilator such as 2, 6- bis-(diethanolamino)-4, 8-dipiperidino pyrimido [5, 4-d] pyrimidine, 3-(#-diethylamino ethyl)- 4-methyl-7-carbethoxymethoxy-2-oxo-2H - chromen, 3, 3'-(N, N'-dimethylethylenediamino)- bis-(propyl 3, 4, 5-trimethoxy benzoate, N-3'- phenylpropyl-(2')-1, 1-diphenyl-(3)-amine, α- isopropyl-α-[N-(methyl-N-homoveratryl)- y - aminopropyl]-3, 4-dimethoxy phenyl-acetonitrile or L-#-(#-hydroxy-α-methyl-phenylethylamino)-3-methoxypropiophenone. The compositions may be administered orally, parenterally or rectally in the form of granules, tablets, coated tablets, capsules, pills, syrups, emulsions, suspensions, powders, drops, suppositories or injection solutions.
Inventors:
ERUNSUTO OTSUTOO RENTO
ANTON MENTORUPU
BUERUHERUMU FURORUKE
ANTON MENTORUPU
BUERUHERUMU FURORUKE
Application Number:
JP10644175A
Publication Date:
January 05, 1977
Filing Date:
September 02, 1975
Export Citation:
Assignee:
BOEHRINGER SOHN INGELHEIM
International Classes:
C07D317/58; A61K31/135; A61K31/235; A61K31/24; A61K31/275; A61K31/33; A61K31/35; A61K31/36; A61K31/495; A61K31/505; A61P3/06; A61P7/02; A61P25/00; C07D241/00; C07D241/04; C07D295/04; C07D295/08; C07D405/06; C07D405/10; C07D407/06; C07D317/50; A61K; C07D; (IPC1-7): A61K31/495; C07D405/06