METHOD FOR MODULATING INFLAMMATORY RESPONSE

Japanese Patent JP2012021010

A

To provide a method for treating a hyperimmune respnse.

There is provided a new method for modulating an immune response in an animal, which includes administering to the animal an effective amount of an agent that increases IL-27R/WSX-1 activity. Further, there is provided a pharmaceutical composition comprising an effective amount of an agent that increases IL-27R/WSX-1 activity. As a material increasing IL-27R/WSX-1 activity, IL-27; recombinant IL-27; active fragment of IL-27; agonist antibody; or IL-27R binding antibody fragment or the like to increase IL-27R activity is exemplified.

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HUNTER CHRISTOPHER
VILLARINO ALEJANDRO

JP2011183763A

February 02, 2012

August 25, 2011

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UNIV PENNSYLVANIA

A61K39/395; A61K6/00; A61K31/00; A61K38/00; A61K38/17; A61K38/19; A61K38/20; A61K45/00; A61P11/06; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07K16/28; A61K

US20020164609A1

2002-11-07

JPN6010009647; ＩＭＭＵＮＩＴＹ １６（６）, 2002, Ｐ．７７９-７９０
JPN7010000539; Ｊ．　ＩＭＭＵＮＯＬ． １７０（１０）, 20030515, Ｐ．４８８６-４８９０
JPN6010009649; ＩＭＭＵＮＩＴＹ １５（４）, 2001, Ｐ．５６９-５７８

Hidekazu Miyoshi
Masakazu Ito
Yuko Hara

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