Title:
METHOD OF MODULATING RAMP ACTIVITY
Document Type and Number:
Japanese Patent JP3639555
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a genetically modified nonhuman mammal and a genetically modified animal cell containing a disrupted RAMP1, RAMP2 or RAMP3 gene, and further to provide a method of screening for an agent that modulates the activity or expression of a RAMP and a method of treating a mammal to modulate liver function and/or muscle metabolism.
SOLUTION: The method of treating a disorder involving administering an agent that modulates RAMP1 activity, and the method of confirming an active substance for modulating the RAMP1, the RAMP2 or the RAMP3 activities comprise (a) contacting the active substance with a mammal cell derived from a female or male reproductive tract, or the skin, and measuring the RAMP1 activity, (b) contacting the active substance with a mammal spermatogenic cell, and measuring the RAMP2 activity, and (c) contacting the active substance with a mammal cell derived from the caudate putamen, the laterodorsal thalamic region of the cerebrum or the male reproductive tract, and measuring the RAMP3 activity.
Inventors:
John Douglas McNaysh
Walter curl solar
John Fenton Thompson
Walter curl solar
John Fenton Thompson
Application Number:
JP2001360473A
Publication Date:
April 20, 2005
Filing Date:
November 27, 2001
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K45/00; A61K49/00; A61P1/16; A61P3/08; A61P9/04; A61P9/10; A61P9/12; A61P15/00; A61P17/00; A61P21/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07K14/705; C12N5/08; C12N5/10; A01K67/027; C12N15/09; C12N15/85; C12Q1/02; A61K38/00; (IPC1-7): A01K67/027; A61K45/00; A61P1/16; A61P3/08; A61P9/04; A61P9/10; A61P9/12; A61P15/00; A61P17/00; A61P21/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C12N5/10; C12N15/09; C12Q1/02
Foreign References:
| WO2000012105A1 |
Other References:
Nature,Vol.393,No.6683(1998)p.333-339
Dev.Biol.,Vol.212,No.2(1999)p.307-322
Dev.Biol.,Vol.212,No.2(1999)p.307-322
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Tadahiko Kurita
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Tadahiko Kurita