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Title:
METHOD FOR OPTICAL RESOLUTION OF RACEMIC ACID
Document Type and Number:
Japanese Patent JPH021466
Kind Code:
A
Abstract:

PURPOSE: To easily obtain a useful title compd. as an intermediate without using an optically active substance by a method wherein sodium salt of a racemic mixture is separated by supersaturation and it is separated by acidification with acetic acid, etc.

CONSTITUTION: Sodium salt of the racemic mixture is separated from a compd. of formula by supersaturation and from sodium salt of enantiomer separated by acidification with acetic acid or a mineral acid, (2S or 3S) (2R or 3R)-2- hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)propionic acid is obtd. In the method, a supersaturation soln. of sodium salt of the (2S or 3S) (2R or 3R) acid can be obtd. by using a lower alcohol or a lower ketone contg. different amt. of water or being anhydrous. Methanol contg. 2-4% water is especially pref.


Inventors:
Piselli, Fulvio L.
Application Number:
JP1989000014941
Publication Date:
January 05, 1990
Filing Date:
January 24, 1989
Export Citation:
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Assignee:
IND CHIM PROFARMACO SPA
International Classes:
C07B57/00; C07C319/28; C07C323/00; C07C323/56; C07D281/10; C07C323/41; (IPC1-7): C07B57/00; C07C319/28; C07C323/56; C07D281/10
Domestic Patent References:
JPS57136581A1982-08-23