METHOD FOR PREPARATION OF LIPID-ENCAPSULATED THERAPEUTIC AGENT

Title:

METHOD FOR PREPARATION OF LIPID-ENCAPSULATED THERAPEUTIC AGENT

Document Type and Number:

Japanese Patent JP2011225618

Kind Code:

A

Abstract:

To generate fully lipid-encapsulated therapeutic agent particles.

A charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation are formed. The lipid vesicles are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles.

Inventors:

MAURER NORBERT
WONG KIM F
CULLIS PIETER R

Application Number:

JP2011172656A

Publication Date:

November 10, 2011

Filing Date:

August 08, 2011

Export Citation:

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Assignee:

UNIV BRITISH COLUMBIA

International Classes:

A61J3/07; A61K9/127; A61K31/711; A61K9/133; A61K31/7125; A61K45/00; A61K47/10; A61K47/12; A61K47/16; A61K47/18; A61K47/24; A61K47/28; A61K47/34; A61K47/48; A61K48/00

Foreign References:

WO1998051278A2

1998-11-19

Attorney, Agent or Firm:

Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio

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