Title:
METHOD OF PREPARING 2-METHOXYESTRADIOL OF HIGH PURITY
Document Type and Number:
Japanese Patent JP2012211132
Kind Code:
A
Abstract:
To provide a 2-methoxyestradiol free of foreign substances.
The 2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification method involves the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.
Inventors:
AGOSTON GREGORY E
TRESTON ANTHONY M
SHAH JAMSHED H
TRESTON ANTHONY M
SHAH JAMSHED H
Application Number:
JP2012096749A
Publication Date:
November 01, 2012
Filing Date:
April 20, 2012
Export Citation:
Assignee:
ENTREMED INC
International Classes:
A61K31/565; C07J1/00; A61P9/00; A61P9/10; A61P15/00; A61P15/08; A61P17/02; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07B61/00; C07C41/36; C07C43/23
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Shinichi Sanuki
Takeshi Niwa
Shinichi Sanuki
Takeshi Niwa
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