Title:
METHOD OF PREPARING 3-[2-{(METHYLSULFONYL)OXY}ETHOXY]-4-(TRIPHENYLMETHOXY)-1-BUTANOL METHANESULFONATE
Document Type and Number:
Japanese Patent JP2008263985
Kind Code:
A
Abstract:
To produce (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methanesulfonate.
The invention provides a method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methanesulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one isomer from the reaction product mixture. Following resolution, the following steps are performed: reducing the isomer to an alcohol; reacting the alcohol with triphenylmethyl chloride; ozonizing the resulting reaction product; reducing the ozonized product to yield a diol; and reacting the diol with a methanesulfonyl compound to produce the target substance.
Inventors:
CAILLE JEAN-CLAUDE
Application Number:
JP2008112946A
Publication Date:
November 06, 2008
Filing Date:
April 23, 2008
Export Citation:
Assignee:
PPG IND OHIO INC
International Classes:
C12P11/00; C07C303/28; C07C309/66; C07D309/24; C12P41/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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