Title:
(R)-または(S)-アミノカルニチン分子内塩、その塩および誘導体の調製方法
Document Type and Number:
Japanese Patent JP4212473
Kind Code:
B2
Abstract:
A process for the production of (R)- or (S)-aminocarnitine starting respectively from (R)- or (S)-nitryloxycarnitine, through the formation and hydrogenation of the azidocarnitine intermediate with the same absolute configuration is described. (R)-aminocarnitine inner salt is obtained after purification, which is then converted into non-deliquescent salts. Also a process for the preparation of derivatives of (R)- and (S)-aminocarnitine, in particular acylayed or ureic derivatives, having known pharmacological properties, starting from (R)- and (S)-aminocarnitine salts, releasing the aminic function in situ.
Inventors:
Oreste Piccolo
Roberto Castagnani
Paolo de Wit Scarfaro
Roberto Castagnani
Paolo de Wit Scarfaro
Application Number:
JP2003515489A
Publication Date:
January 21, 2009
Filing Date:
July 17, 2002
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
A61P3/10; A61K31/221; C07C227/18; C07C227/16; C07C227/40; C07C229/26; C07C231/02; C07C273/18; C07C233/47
Domestic Patent References:
| JP770017U |
Foreign References:
| WO2001010819A1 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Michiko Matsutani