Title:
鏡像異性的に富化した環式β-アリール又はヘテロアリールカルボン酸の調製方法
Document Type and Number:
Japanese Patent JP5038392
Kind Code:
B2
Abstract:
The present invention relates to a process for the preparation of cis substituted cyclic beta-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined herein and corresponding salts thereof.
Inventors:
Bachmann, Stephan
Scallone, michelangelo
Schneider, Patrick
Scallone, michelangelo
Schneider, Patrick
Application Number:
JP2009503527A
Publication Date:
October 03, 2012
Filing Date:
March 26, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C51/36; C07C61/39; C07D207/16; C07D211/60; C07D333/38; C07D401/04; C07B53/00; C07B61/00
Domestic Patent References:
| JP8073400A | ||||
| JP2009511633A | ||||
| JP2009502963A |
Foreign References:
| US5721251 | ||||
| US5804578 | ||||
| WO2005068427A1 |
Other References:
Feroze Ujjainwalla, Daniel Warner, Thomas F. Walsh, Matthew J. Wyvratt, Changyou Zhou, Lihu Yang, Rubana N. Kalyani, Tanya MacNeil, Lex H. T. Van der Ploeg, Charles I. Rosenblum, Rui Tang, Aurawan Vongs, David H. Weinberg, Mark T. Goulet,Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype,BIOORGANIC & MEDICINAL CHEMISTRY LEETERS,NL,Elsevier B.V.,2003年,vol.13, No.24,p.4431-4435
Arthur G. Schultz, Mark Macielag, David E. Podhorez, Joseph C. Suhadolnik, Rudolph K. Kullnig,Enantioselective Birch reduction and reductive alkylations of chiral 2-phenylbenzoic acid derivatives. Application to the synthesis of hydrofluoren-9-ones, hydrophenanthren-9-ones, and (-)-(1R,2R)-2-phenylcyclohexanamine,Journal of Organic Chemistry,米国,American Chemical Society,1988年,vol.53, No.11,p.2456-2464
Cheng Lin Fang, Hiroshi Suemune, Kiyoshi Sakai,Enantio- and diastereoselective synthesis of β-substituted cycloalkanecarboxylates,Journal of Organic Chemistry,米国,ACS Publications,1992年,vol.57, No.15,p.4300-4303
Arthur G. Schultz, Mark Macielag, David E. Podhorez, Joseph C. Suhadolnik, Rudolph K. Kullnig,Enantioselective Birch reduction and reductive alkylations of chiral 2-phenylbenzoic acid derivatives. Application to the synthesis of hydrofluoren-9-ones, hydrophenanthren-9-ones, and (-)-(1R,2R)-2-phenylcyclohexanamine,Journal of Organic Chemistry,米国,American Chemical Society,1988年,vol.53, No.11,p.2456-2464
Cheng Lin Fang, Hiroshi Suemune, Kiyoshi Sakai,Enantio- and diastereoselective synthesis of β-substituted cycloalkanecarboxylates,Journal of Organic Chemistry,米国,ACS Publications,1992年,vol.57, No.15,p.4300-4303
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito