Title:
ロイコトリエン拮抗物質の調製方法
Document Type and Number:
Japanese Patent JP3640962
Kind Code:
B2
Abstract:
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereofwherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercapto-methyl)cyclopropaneacetic acid with a compound of formula (II)wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).
Inventors:
Boupathi, Mahadevan
McNamara, James M
Sidler, Daniel Earl
Volante, Ralph Pee
Burgan, The James The Ray
McNamara, James M
Sidler, Daniel Earl
Volante, Ralph Pee
Burgan, The James The Ray
Application Number:
JP51815295A
Publication Date:
April 20, 2005
Filing Date:
December 22, 1994
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/47; C07D215/18; A61P11/06; C07C215/14; C07C313/02; C07C323/53; C07D215/12; C07D215/14; (IPC1-7): C07D215/18
Domestic Patent References:
| JP5105665A |
Foreign References:
| EP0565185A1 |
Other References:
J.Org.Chem., 1993年 7月 2日, Vol.58, No.14, p.3731-3735
Attorney, Agent or Firm:
Yoshio Kawaguchi
Toru Nakamura
Takeshi Funayama
Naoya Fushimi
Toru Nakamura
Takeshi Funayama
Naoya Fushimi